Human experimental studies focus on the role of body-brain communication in the development, consequences, and treatment of alcohol and other drug use disorders using psychophysiology, brain imaging, and computational modeling. Longitudinal and daily survey research examine patterns, predictors and consequences of substance use over the life course. Cross-sectional and experimental studies address racial/ethnic disparities in the biopsychosocial mechanisms underlying tobacco and cannabis use disorders. Genetic studies examine molecular and genetic bases of complex brain disorders, including genetic predisposition for alcoholism and drug abuse. Integrative data analytic approaches are used to study which treatments for co-occurring traumatic stress and SUD are most effective and for whom.