Patricia Buckendahl

Assistant Research Professor
Office: 
SMH 103B
Phone: 
848-445-3590

About

Dr. Buckendahl joined the Center of Alcohol Studies in 1999 as a research scientist. Her research has focused primarily on the role that osteocalcin, a major component of bone matrix, plays in extraskeletal physiology. Variables under study includes stressful stimuli (acute severe stress and chronic mild stress), acute and chronic alcohol consumption, variable skeletal loading, and the possible role of the protein in sensory transduction in ganglia and spinal cord. She has worked primarily with rodent animal models, most recently comparing normal wild-type mice with a mutant strain whose osteocalcin gene has been deleted. To conduct this work, she has included a large number of undergraduate research assistants who have continued to medical and graduate training after leaving Rutgers.

Current Research

  • Sensory responses in wild type and osteocalcin (OC knockout) mice
  • Effect of spinal cord injury on recovery and inflammatory response in wild type and OC knockout mice
  • Effect of binge alcohol consumption on inflammatory response in wild type and OC knockout mice
  • In situ hybridization of osteocalcin mRNA and immunolocalization of osteocalcin and other proteins in spinal cord sensory ganglia of wild-type and osteocalcin knockout mice

Grants

  • New Jersey Spinal Cord Injury Research Program: Role Of Osteocalcin In Spinal Cord Injury

Selected Publications

McGee-Lawrence M, Buckendahl P, Carpenter C, Henriksen K, Vaughan M, Donahue S. Suppressed bone remodeling in black bears conserves energy and bone mass during hibernation. J Exp Biol. 2015 Jul 1;218(Pt 13):2067-74. doi: 10.1242/jeb.120725. PubMed PMID: 26157160; PubMed Central PMCID: PMC4510842.

Fagnant HS, Uzumcu M, Buckendahl P, Dunn MG, Shupper P, Shapses SA. Fetal and neonatal exposure to the endocrine disruptor, methoxychlor, reduces lean body mass and bone mineral density and increases cortical porosity. Calcif Tissue Int. 2014 Dec;95(6):521-9. doi: 10.1007/s00223-014-9916-x. Epub 2014 Oct 18. PubMed PMID: 25326143.

Patterson-Buckendahl P, Sowinska A, Yee S, Patel D, Pagkalinawan S, Shahid M, Shah A, Franz C, Benjamin DE, Pohorecky LA. Decreased Sensory Responses in Osteocalcin Null Mutant Mice Imply Neuropeptide Function. Cell Mol Neurobiol (2012) 32 (5):879-889 PubMed PMID: 22350212.

Patterson-Buckendahl, P. Osteocalcin is a stress-responsive neuropeptide. Endocrine Regulations 2011, 45: 11-22.

Pohorecky, LA; Sweeney A; Buckendahl, P. Amphetamine modifies ethanol intake and open field behavior of psychosocially stressed male rats. Psychopharmacology, (2011) 218 (1): 281-292. DOI: 10.1007/s00213-011-2339-8

Kavukcuoglu NB, Patterson-Buckendahl P, Mann AB. Effect of osteocalcin deficiency on the nanomechanics and chemistry of mouse bones. J Mech Behav Biomed Mater. 2009 Aug;2(4):348-54.

Patterson-Buckendahl P, Pohorecky LA, Kubovcakova L, Krizanova O, Martin RB, Martinez, DA, and Kvetnansky R. Ethanol and Stress Activate Catecholamine Synthesis in the Adrenal: Effects on Bone. Ann. N.Y. Acad. Sci. (2008) Dec;1148:542-51.

Martinez, D; Buckendahl, P; Lust, A; Shea-Rangel, K; Hoban-Higgins, T; Fuller, C; Vailas, A. A Non-Invasive Analysis Of Urinary Musculoskeletal Collagen Metabolism Markers From Rhesus Monkeys Subject To Chronic Hypergravity. J Appl Physiol. 2008 Oct;105(4):1255-61.

 Patterson-Buckendahl P, Pohorecky LA, Kvetnansky R. Differing effects of acute and chronic stressors on plasma osteocalcin and leptin.  Stress 10(2): 163-172, 2007.

Fornal CA, Stevens J, Barson JR, Blakley GG, Patterson-Buckendahl P, Jacobs BL.  Delayed suppression of hippocampal cell proliferation in rats following inescapable shocks. Brain Res. 2007 Jan 26;1130(1):48-53.

Tomie A, Hosszu R. Rosenberg RH, Gittleman J, Patterson-Buckendahl P, and Pohorecky LA. An Inter-gender Effect On Ethanol Drinking in Rats:  Proximal Females Increase Ethanol Drinking in Males.  Pharmacology, Biochemistry, and Behavior, 2006 Feb:83(2): 307-313.

Donahue SW, Galley SA, Vaughan MR. Patterson-Buckendahl P, Demers, LM, Vance, JL, and McGee, ME.  Parathyroid hormone may maintain bone formation in hibernating black bears (Ursus americanus) to prevent disuse osteoporosis. J. Exp. Biol, 2006 May: 209(Pt 9): 1630-1638.

Patterson-Buckendahl P, Kubovcakova L, Krizanova O, Pohorecky LA, and Kvetnansky R. Ethanol consumption increases rat stress hormones and adrenomedullary gene expression. Alcohol 2005, Nov;37(3):157-166.

Pohorecky LA, Blakley GG, Kubovcakova L, Krizanova O, Patterson-Buckendahl P,Kvetnansky R. Social hierarchy affects gene expression for catecholamine biosynthetic enzymes in rat adrenal glands. Neuroendocrinology. 2004;80(1):42-51.

Tomie, A., Uveges, J. M., Burger, K. M., Patterson-Buckendahl, P., and Pohorecky, L. A. (2004).  Effects of ethanol sipper and social opportunity on ethanol drinking in rats.  Alcohol and Alcoholism 39(3): 197-202, 2004.

Macho L, Zorad S, Radikova Z, Patterson-Buckendahl P, Kvetnansky R. Ethanol consumption affects stress response and insulin binding in tissues of rats. Endocr Regul.  2003 Dec;37(4):195-202.

Tomie, A., Wong, K., Apor, K., Patterson-Buckendahl, P., and Pohorecky. L. A. (2003).  Autoshaping of ethanol drinking in rats: Effects of ethanol concentration and trial spacing.  Alcohol, 31, 125-135.

Education

PhD, University of California, Santa Cruz, Biology, 1992

Professional Services

  • July 1 2007 to present – Director, Shared Rutgers/RWJMS ex vivo microCT imaging facility.  Responsibilities include recruitment and training of users, instrument maintenance, reporting recharge amounts to university account manager.
  • Served as anonymous reviewer for manuscripts submitted to more than 10 professional journals
  • Outside reviewer of dissertation submitted by Pablo Balino in partial completion of PhD from University of Valencia, Spain.
  • Collaborative summer research with Ms Catherine Ambos, 7th grade biology teacher, Somerville Middle School.

Recent Awards

Research Mentor of the Year Aresty Research Center for Undergraduates 2012

Awards to Students and Junior Faculty Mentored

Jayanth Vatson, Undergraduate Research Assistant CAS Poster Session Award for Animal Experimentation, 2015
Jayanth Vatson Departmental Honors, Cell Biology and Neuroscience, 2015
Amanda Vo Departmental Honors, Cell Biology and Neuroscience, 2015
Bianca Patel, Chloe Schmidt, Jonathan Tsui School of Arts and Sciences Honors, 2013
Devan Murphy George H Cook Honors, 2013
Stephen Pagkalanawan Henry Rutgers Honors, 2012
Christopher Franz, Andrew Greenwald, David Kopylov Henry Rutgers Honors, 2011